https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 TCF4 gene polymorphism is associated with cognition in patients with schizophrenia and healthy controls https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22607 2 = 3.48, p = 0.062 and X2 = 0.036, p = 0.036, respectively). Cognitive test scores were significantly lower in patients than in controls on all scales (all p < 0.001) except for the visuospatial/constructional index (p > 0.05). There were significant genotype effects on delayed memory score (p = 0.013), the RBANS total score (p = 0.028) and language score (p = 0.034). Further analysis showed that the language score significantly differed according to the genotypic groups (A/A+T/A group versus T/T group) (p = 0.007) in patients but not in controls (p > 0.05), and the delayed memory score also significantly differed according to the genotypic groups (A/A+T/A group versus T/T group) (p = 0.021) in controls but not in patients (p > 0.05). Conclusions: This study found that the A allele of the TCF4 rs2958182 polymorphism was the risk allele of schizophrenia, and was associated with lower cognitive performance in language in schizophrenia and delayed memory in controls. In contrast, the T allele of this polymorphism was found to be the schizophrenia risk allele in another study in Han Chinese people.]]> Sat 24 Mar 2018 07:16:05 AEDT ]]> Altered BDNF is correlated to cognition impairment in schizophrenia patients with tardive dyskinesia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22968 Sat 24 Mar 2018 07:15:20 AEDT ]]>